0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children

• Status: Completed
• Trial end date: 2011-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of this study is to compare the mean serum sodium after 48 hours of therapy with either 0.45% NaCl/dextrose 5% or 0.9% NaCl/dextrose 5%, in critically ill children requiring IV maintenance fluid administration.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hospital General de Niños Pedro de Elizalde

Criteria

Inclusion Criteria:

• Age 1 month to 18 years

• ICU stay >24 hours

• Normal seric sodium (135 - 145 mEq/L).

• Requirement of IV maintenance solutions >80% total fluids intake

Exclusion Criteria:

• Patients with diagnoses of renal failure (serum creatinine >1 g/dl in <3 years old children, >1,5 in >3 years), hepatic failure with ascitis and portal hypertension, adrenal failure, nephrotic - nephritic syndrome, Kawasaki disease, sickle cell anemia, Syndrome of inappropriate antidiuretic hormone secretion, diabetes insipidus,metabolic disease.

• Diuretics use in the first 48 hours thereafter indicated IV solutions.

• Plasma glucose is >200 mg%.

• Any patients requiring IV fluids therapy different that maintenance (total parenteral nutrition, hyperhydration).