0,9% NaCl Effect on Kidney Function and Glycocalyx in Patients Operated on for Primary Hiparthrosis

• Status: Unknown status
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if chloride is nephrotoxic using 0,9% saline versus Plasma-Lytein in patients having primary hip replacement surgery. The outcome is found measuring bio markers, vasoactive hormones and salt regulation. And to measure syndecan as a marker for glycocalyx degradation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Regional Hospital Holstebro
• Treatments: Plasma-lyte 148

Criteria

Inclusion Criteria:

• Indication for uncemented primary hiparthroplasty

• age < 60

Exclusion Criteria:

• Blooddonation or transfusion during the last month

• Not willing to participate

• estimated GFR below 30ml/min

• type 1 diabetes