1.2% Atorvastatin and 1.2% Simvastatin in Treatment of Chronic Periodontitis
Status:
Completed
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
Background: Statins are the recently evolved agents that aid in periodontal regeneration and
ultimately attaining periodontal health. Atorvastatin (ATV) and Simvastatin (SMV) are
specific competitive inhibitors of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. The
present study was designed to evaluate and compare the effectiveness of 1.2% ATV, and 1.2%
SMV as an adjunct to scaling and root planing (SRP) in the treatment subjects with chronic
periodontitis.
Methods: Ninety six subjects were categorized into three treatment groups: SRP plus 1.2% ATV,
SRP plus 1.2% SMV and SRP plus placebo. Clinical parameters; full mouth plaque index (PI),
modified sulcus bleeding index (mSBI), probing depth (PD), and relative attachment level
(RAL) were recorded at baseline before SRP and at 3, 6 and 9 months. Percentage radiographic
defect depth reduction was evaluated using computer-aided software at baseline, 6 months and
9 months.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Government Dental College and Research Institute, Bangalore