1% Metformin Gel in the Treatment of Class II Furcation Defects
Status:
Completed
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts
differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a
favourable effect on alveolar bone. The present study aims to explore the efficacy of 1% MF
gel as a local drug delivery system in adjunct to scaling and root planing (SRP) for the
treatment of Class II furcation defects in comparison with placebo gel.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Government Dental College and Research Institute, Bangalore