10 vs 14 Days Triple Therapy : H.Pylori Infection Eradication

• Status: Unknown status
• Trial end date: 2017-05-12
• Target enrollment: 0
• Participant gender: All

Summary

Helicobacter pylori is a bacterium estimated to colonize in the gastrointestinal tract of the half population in the world. Colonization of this bacteria is suspected to be one of the main risk factor for the occurrence of various abnormalities of the upper gastrointestinal tract, such as peptic ulcer and gastrointestinal cancer. The Experts recommend giving triple therapy regimens as first-line eradication therapy for Helicobacter pylori infection. The recommended duration of triple therapy is 10-14 days. However, recent studies suggest triple therapy with longer duration will provide a higher percentage of eradication. This study wanted to show whether 14 days of triple therapy was better than 10 days in Helicobacter pylori eradication.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indonesia University
• Treatments: Amoxicillin; Clarithromycin; Rabeprazole

Criteria

Inclusion Criteria:

• 18 years or older patients who are proven to be infected by Helicobacter pylori based on positive in Urea Breath Test or positive in histopathologic examination of biopsy in antrum and corpus of gaster through esophagoduodenoscopy.

Exclusion Criteria:

• Patients refuse to follow the research

• Patient has had previous eradication therapy of Helicobacter pylori infection.

• The patient is pregnant or breastfeeding

• Patients have a history of allergy to one component of triple therapy regimen (proton pump inhibitor, penicillin, and / or macrolide) before.

• Patients are known to have impaired liver function, evidenced by ALT values within normal limits, and no previous liver disease.

• Patients were found to have arrhythmias or obtained QT wave elongation on electrocardiographic