17-AAG and Irinotecan in Treating Patients With Locally Advanced or Metastatic Solid Tumors

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This phase I trial is studying the side effects and best dose of 17-AAG and irinotecan in treating patients with locally advanced or metastatic solid tumors. Drugs used in chemotherapy, such as 17-AAG and irinotecan, work in different ways to stop the growth of tumor cells either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cancer Institute (NCI)
• Treatments: Camptothecin; Irinotecan

Criteria

Inclusion Criteria:

• Histologically confirmed solid tumor, excluding primary CNS tumors

• Locally advanced or metastatic disease that is refractory to standard therapy OR for which no standard therapy exists

• Tumor assessible for biopsy by Tru-cut^®, CT guidance, or endoscopy (for patients treated at the maximum tolerated dose [expanded cohort only])

• Pleural effusions or abdominal ascites are not considered biopsy-accessible tissue

• No known new CNS metastases that have not been previously treated

• Performance status - Karnofsky 60-100%

• WBC ≥ 3,000/mm^3

• Absolute neutrophil count ≥ 1,500/mm^3

• Platelet count ≥ 100,000/mm^3

• Bilirubin ≤ 1.5 mg/dL

• AST and ALT ≤ 3 times upper limit of normal (ULN) (5 times ULN if liver metastases are present)

• Creatinine ≤ 1.5 mg/dL

• No history of cardiac arrhythmias

• No myocardial infarction within the past 12 months

• No active ischemic heart disease within the past 12 months

• No New York Heart Association class III-IV congestive heart failure or LVEF < 40% by MUGA

• No history of uncontrolled cardiac dysrhythmia or dysrhthmias requiring medication

• No history of serious ventricular arrhythmia (i.e., ventricular tachycardia or ventricular fibrillation ≥ 3 beats in a row)

• No congenital long QT syndrome

• No left bundle branch block

• QTc < 450 msec (for male patients)

• QTc < 470 msec (for female patients)

• Not pregnant

• No nursing during and for 2 months after study participation

• Negative pregnancy test

• Fertile patients must use effective contraception during and for 2 months after study participation

• No serious or uncontrolled infection

• No history of serious allergic reaction to eggs or egg products

• No other medical condition that would preclude study participation

• At least 3 weeks since prior immunotherapy

• No concurrent prophylactic filgrastim (G-CSF) or sargramostim (GM-CSF)

• At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)

• Prior irinotecan allowed

• No prior 17-N-allylamino-17-demethoxygeldanamycin (17-AAG)

• At least 2 weeks since prior non-myelosuppressive chemotherapy (at the discretion of the principal investigator)

• At least 3 weeks since prior radiotherapy

• No prior radiotherapy field that included the heart (e.g., mantle)

• Recovered from all prior therapy

• At least 3 weeks since prior anticancer investigational therapeutic drugs

• More than 7 days since prior and no concurrent inducers, inhibitors, or modifiers of CYP3A4, including any of the following:

• Fluconazole

• Itraconazole

• Ketoconazole

• Azithromycin

• Clarithromycin

• Erythromycin

• Troleandomycin

• Nifedipine

• Verapamil

• Diltiazem

• Nefazodone

• Cyclosporine

• Grapefruit juice (> 1 quart/day)

• Indinavir

• Nelfinavir

• Ritonavir

• Saquinavir

• Carbamazepine

• Phenobarbital

• Phenytoin

• Rifampin

• Hydrastis canadensis (goldenseal)

• Hypericum perforatum (St. John's wort)

• Uncaria tomentosa (cat's claw)

• Echinacea angustifolia root

• Trifolium pratense (wild cherry)

• Matricaria chamomila (chamomile)

• Glycyrrhiza glabra (licorice)

• Dillapiol

• Hypericin

• Naringenin

• No concurrent medications that would prolong QTc

• No concurrent vitamins, antioxidants, herbal preparations, or supplements

• Concurrent single daily multivitamin allowed

• No other concurrent anticancer therapy

• No concurrent combination antiretroviral therapy for HIV-positive patients

• No other concurrent investigational medications