18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer

• Status: Recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

PyL, also known as [18F]DCFPyL, is a second-generation fluorinated prostate-specific membrane antigen (PSMA) targeted PET imaging agent. In preliminary studies it demonstrates a higher detection of metastatic prostate lesions compared to standard imaging. Its ability to image metastatic prostate cancer sites was comparable to 68Ga-PSMA with high tumor-to-background ratios.Additionally, [18F] PyL demonstrated higher mean tumor-to-background ratios when using kidney, spleen, or parotid as reference organs. However, the role of [18F] PyL in tumor response to therapy has not been evaluated, specifically the potential to serve as a predictive biomarker of response. Given the high cost of current therapeutic agents in mCRPC, there is a need for an early response biomarker to stratify which patients will benefit from therapy and which will not. This will also allow for earlier change in management of patients who will not response to these therapies, potentially improving patient outcomes.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Columbia University

Criteria

Inclusion Criteria:

1. Histologically confirmed diagnosis of prostate cancer

2. PSA ≥ 0.2ng/ml

3. Age ≥ 18 years of age

4. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (karnofsky ≥ 60%)

5. Ability to understand and willingness to sign a written informed consent document

6. Wiling to comply with clinical trial instructions and requirements

7. Willing to cover the cost of PyL PET/CT imaging if funds are not available

Exclusion Criteria:

1. History of another active malignancy within 3 years, other than basal cell and squamous cell carcinoma of the skin

2. Presence of prostate brachytherapy implants unless approved by the PI

3. Administration of another radioisotope within five physical half-lives of trial enrollment

4. Radiation or chemotherapy within 2 weeks prior to trial enrollment

5. Serum creatinine > 3 times the upper limit of normal

6. Serum total bilirubin > 3 times the upper limit of normal

7. Aspartate transaminase (AST) or alanine aminotransferase (ALT) >5 times the upper limit of normal

8. Inadequate venous access