Overview

18F-DOPA-PET in Finding Tumors in Patients With Newly Diagnosed Gliomas Undergoing Radiation Therapy

Status:
Active, not recruiting
Trial end date:
2023-12-14
Target enrollment:
0
Participant gender:
All
Summary
This phase II trial studies how well fluorine F 18 fluorodopa (18F-DOPA)-positron emission tomography (PET) works in finding tumors in patients with newly diagnosed gliomas undergoing radiation therapy. Comparing results of diagnostic procedures done before and during radiation therapy may help doctors predict a patient's response to treatment and help plan the best treatment.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mayo Clinic
Collaborator:
National Cancer Institute (NCI)
Treatments:
Dacarbazine
Dihydroxyphenylalanine
Temozolomide
Criteria
Inclusion Criteria:

- Histologically confirmed newly diagnosed grade IV malignant glioma; Note: grade III
patients are no longer being enrolled

- Computed tomography (CT) simulation, immobilization, MRI and PET imaging, treatment
planning, and all follow-up MRI and PET scans to be performed at Mayo Clinic
Rochester; Note: the actual radiation therapy treatments and follow-up other than
imaging can be performed at Mayo Clinic Rochester, Northfield, LaCrosse, Mankato, Eau
Claire, or Albert Lea

- Provide written informed consent

- Ability to complete questionnaire(s) by themselves or with assistance

Exclusion Criteria:

- Patients diagnosed with anaplastic oligodendroglioma

- Unable to undergo MRI scans with contrast (e.g. cardiac pacemaker, defibrillator,
kidney failure)

- Unable to undergo an 18F-DOPA PET scan (e.g. Parkinson's disease, taking
anti-dopaminergic, or dopamine agonist medication or less than 6 half-lives from
discontinuance of dopamine agonists); NOTE: other potentially interfering drugs
consist of: amoxapine, amphetamine, benztropine, bupropion, buspirone, cocaine,
mazindol, methamphetamine, methylphenidate, norephedrine, phentermine,
phenylpropanolamine, selegiline, paroxetine, citalopram, and sertraline; if a patient
is on any of these drugs, list which ones on the on-study form

- Any of the following:

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception