1H Magnetic Resonance Spectroscopy in Migraine Patients

• Status: Completed
• Trial end date: 2016-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

To investigate the glutaminergic system in the onset of migraine-like attacks.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Leiden University Medical Center
• Collaborators: European Commission; Netherlands Organisation for Scientific Research
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• Diagnosed with migraine without aura according to the International Classification of Headache Disorders (ICHD)-3 beta criteria from 2013.

• At least one migraine attack per month in the preceding six months

Exclusion Criteria:

• Other neurological disorders apart from migraine

• Chronic medication apart from oral contraceptives

• Migraine with aura

• Chronic migraine with 15 or more headache days per month/with 8 or more migraine days per month

• Medication-overuse headache (ICHD-3 beta criteria)

• Women who are breastfeeding, pregnant, or planning to become pregnant

• Contra-indications for 7 tesla MRI scanner

• Contra-indications for GTN administration (e.g. nitrate allergy, heart condition)

• Healthy controls (with no first degree relative with migraine or trigeminal autonomic cephalalgia)