2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
Status:
Unknown status
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
Dental treatments, particularly third molars extraction, can become extremely uncomfortable
and painful. They are associated to anxiety, fear and many other unpleasant sensations.
During surgery, patients can present cardiorespiratory repercussions of these sensations.
This fact generally justifies the employment of methods of monitoring and appliance of safer
therapeutic alternatives. Local anesthetics are the most frequently drugs used in dentistry.
Vasoconstrictors, particularly epinephrine, are important components of anesthetic solutions
to increased time for anesthetic absorption and consequently increasing the duration of
anesthesia. The use of smaller amounts of anesthetic solution can reduce the risk of systemic
toxicity, however decrease the total surgical time. It is well known that the amount of
epinephrine injected into patients during anesthetic procedures can produce adverse
hemodynamic effects. Levonordefrin was adding to dental cartridges promising to reduce
cardiac stimulation due it less β activity, and maintain the same clinical and systemic
effects. But some studies for maxillary or intraosseous infiltrations showed no difference in
heart rate and any anesthetic success over epinephrine. Thus, this study aims to compare the
clinical efficacy and safety of anesthetic mepivacaine 2% with epinephrine 1:100,000 or
1:20,000 levonordefrin employing a clinical trial model of third molars extractions in
healthy adults.