3D PET Myocardial Blood Flow and Rb82 Infusion Profiles

• Status: Recruiting
• Trial end date: 2022-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The investigators seek to test bolus infusions (50ml/min) vs. slow infusions (20 ml/min) of Rb-82 on metrics of coronary blood flow assessed on a modern 3D PET/CT.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ochsner Health System
• Collaborator: Bracco Corporate

Criteria

Inclusion Criteria:

Normal Volunteers

• Adults ≥18 and <40 years old able to give informed consent.

• Ability to abstain from caffeine for 48 hours

The "clinical" population

• Adults ≥18 years old able to give informed consent.

• Any cardiac risk factor including hypertension, hyperlipidemia, diabetes mellitus or tobacco use OR

• CAD defined by with history of PCI or CABG, Coronary Ca score>400, or dense coronary calcifications noted on chest CT

• Ability to abstain from caffeine for 48 hours

The "infarct" population

• Adults ≥18 years old able to give informed consent.

• Prior cardiac PET scan demonstrating a fixed defect ≥ 15% of the LV myocardium with relative uptake ≤60% maximum uptake.

• In addition, to the perfusion defect, each volunteer requires either:

• FDG PET or MRI viability studies confirming infarct OR

• akinesis and wall thinning on ECHO within the same territory as the PET defect in addition to Q-waves on ECG

• Ability to abstain from caffeine for 48 hours

Exclusion Criteria:

Normal Volunteers

• Any chronic cardiac disease or condition (e.g., hypertension, hyperlipidemia)

• Any chronic systemic disease or condition (e.g., diabetes, systemic lupus, rheumatoid arthritis)

• Tobacco use

• Family history in a first degree relative with clinical CAD (h/o PCI, MI or CABG) in men <55 or women <65

• Severe claustrophobia

• Positive urine pregnancy test

• Inability to give informed consent

• BMI ≥ 30 or BMI>25 and <30 provided waist to hip ratio >0.80 in women or 0.90 in men.

The "clinical" and "infarct" populations

• Severe claustrophobia

• Hemodynamic instability or unstable symptoms

• Positive urine pregnancy test

• Inability to give informed consent