4-methylpyrazole and Acetaminophen Metabolism

• Status: Completed
• Trial end date: 2018-10-31
• Target enrollment: 0
• Participant gender: All

Summary

Oxidative metabolism of APAP will be studied with and without 4-MP.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Arizona
• Treatments: Acetaminophen; Fomepizole

Criteria

Inclusion Criteria:

• Healthy

• No APAP use in previous 2 weeks

• No ingestion of alcohol or drugs that affect CYP 2E1 over previous 5 days

• No allergy to APAP or fomepizole

• BMI < 29

Exclusion Criteria:

• Pregnant or lactating

• History of alcohol abuse

• Allergy to APAP or fomepizole

• Screening LFTs above normal range