5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab
Status:
Terminated
Trial end date:
2019-10-03
Target enrollment:
Participant gender:
Summary
This randomized trial studies how well panitumumab, leucovorin calcium, and fluorouracil
after combination chemotherapy and panitumumab induction work in treating patients with RAS
wild type colorectal cancer that has spread from where it started to nearby tissue or lymph
nodes or other places in the body or cannot be removed by surgery. Monoclonal antibodies,
such as panitumumab, may interfere with the ability of tumor cells to grow and spread. Drugs
used in chemotherapy, such as leucovorin calcium, fluorouracil, and oxaliplatin, work in
different ways to stop the growth of tumor cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. Giving panitumumab, leucovorin
calcium, and fluorouracil after combination chemotherapy and panitumumab induction may work
better in treating patients with colorectal cancer.