5 Versus 10 Units of Insulin in Hyperkalemia Management

• Status: Recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to compare 5 units of intravenous Regular insulin to 10 units of intravenous regular insulin in the management of hyperkalemia. We will measure the efficacy of these 2 doses of insulin in reducing hyperkalemia at 2 hours from administration using the main laboratory serum values.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Oman Medical Speciality Board
• Collaborator: Sultan Qaboos University
• Treatments: Albuterol; Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Hyperkalemia patients with lab potassium levels equal to or more than 5.5 mEq/L (≥ 5.5 mEq/L)+.

• Adult: age 18 years or more.

• Agreed to participate in the study.

• If an investigator decides to start anti-hyperkalemia medications based on the VBG/ABG patient can be enrolled but if the main laboratory value is less than 5.5 mEq/L patients will be excluded

Exclusion Criteria:

• Cardiac arrest

• Hyperglycemia with random blood sugar 20 mmol/L (13) or with acute diabetic complications like Diabetic Ketoacidosis / Hyperosmolar Hyperglycemic State.

• Hypoglycemia with random blood sugar (RBS) ≤ 3.89 mmol/l in Diabetic patients and less than 3 mmol/l in non-diabetic patients.

• Allergies for any medication in the protocol.

• Pregnancy.

• Hemolyzed potassium level as reported by the main lab.

• Hemolysis, Tumor lysis syndrome, or Rhabdomyolysis due to the ongoing release of potassium.

• Acidosis with a pH less than 7.1 will require Sodium bicarbonate (NaHO3).

• A patient who will need urgent Furosemide (Lasix), and or dialysis during the study period of 2 hours.

• Refused to participate.