Overview

64Cu-DOTA Pembrolizumab for Imaging Metastatic Solid Tumors in Patients Receiving Stereotactic Body Radiation

Status:
Not yet recruiting
Trial end date:
2026-11-08
Target enrollment:
0
Participant gender:
All
Summary
This clinical trial tests how well using 64Cu-DOTA pembrolizumab (64CDP) with positron emission tomography (PET) scans works to find tumor cells in patients with cancers that have spread from where it first started to other places in the body (metastatic). 64CDP is a compound with pembrolizumab that is joined with a radioactive substance used for diagnostic purpose. Pembrolizumab is in a class of medications called monoclonal antibodies. It works by helping your immune system to slow or stop the growth of cancer cells. Targeted drugs such as pembrolizumab may the improve uptake of the radioactive substance in tumor cells. 64CDP may improve ability to evaluate response to treatment in patients with solid tumors.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
City of Hope Medical Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
Copper
Pembrolizumab
Criteria
Inclusion Criteria:

- Documented informed consent of the participant and/or legally authorized
representative.

- Assent, when appropriate, will be obtained per institutional guidelines

- Age: >= 18 years

- Karnofsky performance status (KPS) >=70

- Patients with metastatic disease from a solid-tumor malignancy currently being treated
with single-agent pembroilizumab, who have been referred for stereotactic body
radiation therapy (SBRT) for consolidative local therapy or for oligo
resistant/progressive disease

- Sites that amenable to SBRT are located in lymph nodes, bone/spine, or lung

- Brain metastases or cases with intra-cranial progression are allowed, but an
additional extra-cranial site planned for SBRT is required

- Absolute neutrophil count (ANC) >= 1000/mm^3

- Platelet count >= 50/mm^3; platelet transfusions to help patients meet eligibility
criteria are not allowed within 7 days before study enrollment

- Total bilirubin =< 1.5 x the upper limit of normal (ULN)

- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN

- Calculated creatinine clearance >= 30mL/min

- Contraception:

- Woman of childbearing potential must be practicing a highly effective method of
birth control consistent with local regulations regarding the use of birth
control methods for subjects participating in clinical studies: e.g., established
use of oral, injected or implanted hormonal methods of contraception; placement
of an intrauterine device or intrauterine system; barrier methods; condom with
spermicidal foam/gel/film/cream/suppository or occlusive cap (diaphragm or
cervical/vault caps) with spermicidal foam/gel/film/cream/suppository; male
partner sterilization; true abstinence (when this is in line with the preferred
and usual lifestyle of the subject) during and after the study (6 months after
the last dose of 64Cu-anti-PD1 [pembrolizumab]-NHS-DOTA for women);

- A man who is sexually active with a woman of childbearing potential and has not
had a vasectomy must agree to use a barrier method of birth control, e.g., either
condom with spermicidal foam/gel/film/cream/suppository or partner with occlusive
cap (diaphragm or cervical/vault caps) with spermicidal
foam/gel/film/cream/suppository, and all men must also not donate sperm during
the study and for 6 months after receiving the last dose of study drug

Exclusion Criteria:

- Patient planned to stop Pembrolizumab at time of referral for SBRT

- Patient unable to tolerate positron emission tomography (PET) scan even with
anxiolytic medications

- Any other condition that would, in the Investigator's judgment, contraindicate the
patient's participation in the clinical study due to safety concerns with clinical
study procedures

- Vaccination with live attenuated vaccines within 4 weeks of study agent administration
except forthcoming COVID-19 vaccines

- Subject is currently using or has used immunosuppressive medication within 14 days
prior to the study agent administration with the exception of:

- Intranasal, topical, inhaled, or local steroid injections (e.g., intra-articular
injection);

- Chronic systemic corticosteroids at physiologic doses not to exceed 10 mg/day of
prednisone or equivalent;

- Steroids as premedication for hypersensitivity reactions (e.g., infusion-related
reactions, CT scan premedication)

- Female patients who are lactating or have a positive pregnancy test during the
screening period

- Infection requiring systemic antibiotic therapy within 14 days prior to start of study
treatment

- Subject has plasma cell leukemia, Waldenstrom's macroglobulinemia, POEMS syndrome
(polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes),
or primary amyloidosis

- Prospective participants who, in the opinion of the investigator, may not be able to
comply with all study procedures (including compliance issues related to
feasibility/logistics)