68Ga-N188 PET/CT Imaging in Malignancy

• Status: Recruiting
• Trial end date: 2025-07-31
• Target enrollment: 0
• Participant gender: All

Summary

The Nectin-4 protein belongs to the cell adhesion factors family and has a tissue-specific expression spectrum in normal human tissues. However, Nectin-4 is overexpressed in various malignancies, especially those of epithelial origins, such as uroepithelial carcinoma, making Nectin-4 a highly specific and significant imaging target for malignancies.

[68Ga]N188, a novel molecular probe of PET imaging agent that targets Nectin-4, can be used in the diagnosis and research of a wide variety of Nectin-4 high-expression malignancies, including bladder cancer.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Peking University First Hospital

Criteria

Inclusion Criteria:

• patients with confirmed or suspected cancer;

• 18F-FDG PET/CT within 1 week;

• Signed written informed consent.

Exclusion Criteria:

• Pregnant and lactating women;

• Female patients plan to become pregnant within 6 months.