7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung Cancer
Status:
Completed
Trial end date:
2010-06-01
Target enrollment:
Participant gender:
Summary
This phase II trial is studying how well giving UCN-01 together with topotecan works in
treating patients with small cell lung cancer that relapsed or progressed after previous
chemotherapy. Drugs used in chemotherapy, such as topotecan, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
UCN-01 may stop the growth of tumor cells by blocking some of the enzymes needed for cell
growth. It may also increase the effectiveness of topotecan by making tumor cells more
sensitive to the drug. Giving UCN-01 together with topotecan may kill more tumor cells.