71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has been suggested in previous studies.

Given the role of 17b-HSD5 in androgenic metabolism producing testosterone from precursors, the investigators hypothesis is that women with PCOS and with the variant allele G have a poor response on hirsutism and on hormonal and metabolic variables after oral contraceptive pill (OCP) treatment for 6 months.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federal University of Rio Grande do Sul
• Collaborators: Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.; Hospital de Clinicas de Porto Alegre
• Treatments: Contraceptive Agents; Contraceptives, Oral; Contraceptives, Oral, Combined

Criteria

Inclusion Criteria:

• hirsute women with polycystic ovary syndrome

Exclusion Criteria:

• Use of any drugs known to interfere with hormone levels for at least 3 months before the study

• Women with type 2 diabetes, homa index > 3.8, liver or renal disease or thyroid dysfunction

• Other hyperandrogenic disorders than PCOS