8mm-TIPS Versus Endoscopic Variceal Ligation (EVL) Plus Propranolol for Prevention of Variceal Rebleeding

• Status: Unknown status
• Trial end date: 2020-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study was to conduct a prospective randomized trial to compare TIPS with 8mm expanded polytetrafluoroethylene(ePTFE)-covered stents and endoscopic variceal ligation plus propranolol for the prevention of recurrent esophageal variceal bleeding.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: West China Hospital
• Treatments: Propranolol

Criteria

Inclusion Criteria:

1. Cirrhosis

2. Patients who had bled from esophageal varices (≥5days and ≤28days)

3. Child-Pugh B or Child-Pugh C≤13

Exclusion Criteria:

1. THE presence of gastric varices

2. Non-cirrhotic portal hypertension

3. Portal vein thrombosis

4. The history of hepatic encephalopathy

5. Total bilirubin ≥51.3 umol/L

6. Previous treatment of TIPS or surgery

7. Proven malignancy including hepatocellular carcinoma

8. Contraindications to TIPS、EVL or propranolol

9. End-stage renal disease under renal replacement therapy;

10. Cardiorespiratory failure

11. Pregnancy or patients not giving informed consent for endoscopic procedures