A 6 Months Double Blind Trial to Prevent PONV in Laparoscopic Cholecystectomy
Status:
Not yet recruiting
Trial end date:
2023-04-01
Target enrollment:
Participant gender:
Summary
As long as anesthesia is administered, postoperative nausea and vomiting (PONV) will continue
to be a frequent and upsetting comorbidity. Vomiting and nausea can significantly slow down
recovery, raise staffing and drug expenses, and decrease patient satisfaction during
perioperative procedures.
Nausea it is a conscious recognition of subconscious excitation in area of medulla closely
associated with or a part of the vomiting center, or it is sensation of discomfort at upper
abdomen and unease sensation with involuntary order to vomit. While vomiting It is a mean by
which the upper GIT rides of its contents when any part of upper GIT becomes irritated, over
distended or over excitable.
The PONV is the most feared postoperative symptoms & it may impaired dressing , surgical
repairs & increased ( bleeding , pain , risk of gastric contents aspiration ) & if it is
prolonged will leads to electrolytes , fluid imbalance & dehydration ; the PONV can occurs
after up to 90 % of operative procedures ; The common risk factors of PONV are : young age ,
female gender, history of ( PONV , motion sickness ) , those not smokers , early mobilization
after surgery , early drinking & eating after operations , procedures like (laparoscopic ,
gynecological , abdominal , ENT , squint ) , postoperative severe pain , narcotic
premedication , possibly prolonged general anesthesia , gastric distention , stimulation of
the pharynx , hypoxemia , hypotension , & dehydration.
The PONV can reduced by: avoidance of triggers where possible, uses of anti-emetics drugs,
techniques & procedures associated with low incidence of PONV (e.g. propofol) & give
intravenous fluids; with prophylaxis the incidence is usually under 30% in high risk cases,
the most effective approach for prevention of PONV is the use of multiple strategies &
different drugs.
The pregabalin (C8H17NO2), is a newer drug & recently introduced at 1990. as anticonvulsive
medication. We evaluated the effect of oral pregabalin on postoperative nausea and vomiting
in laparoscopic cholecystectomy cases.