A Biotype Enhancing Strategy For The Patient Undergoing Accelerated Orthodontics
Status:
Unknown status
Trial end date:
2018-09-01
Target enrollment:
Participant gender:
Summary
Numerous treatment protocols geared towards accelerating orthodontic treatment have emerged
in the past few years as an appealing alternative for patients and practitioners. In the
context of a thin biotype, these approaches pose a burden that could precipitate periodontal
detrimental changes. Therefore, case selection and the implementation of periodontal biotype
enhancing strategies become a relevant consideration to ensure long-term successful treatment
outcomes. This study focuses on the biological and clinical value of the use of a porcine
naturally cross-linked collagen matrix known as Mucograft®. Within the scope of Surgically
Accelerated Orthodontic Treatment (SAOT) the structural and material features of Mucograft®
provide: 1) A protective effect to the thin biotype upon rapid orthodontic
protusive/proinclination movements and 2) Mucograft® enhances the therapeutic window effect
that supports an increase on tooth movement rate. The designs of this randomized controlled
clinical trial includes a cohort of 40 subjects distributed on the following groups I) Ortho
tx, II) Ortho tx + Decortication, III) Ortho tx + Decortication + Mucograft®, and IV) Ortho
tx + Mucograft®. Comparing clinical, tomographic and digital impression derived measurements
will capture the clinical phenotype; while the biologic phenotype will be derived from
evaluating crevicular fluid levels of tooth movement mediators such as Interleukin 1-β and
Interleukin-1RA. The significance and innovative value of this proposal stems from the use of
Mucograft® as an ideal collagen-based biotype enhancer when performed along with the
corticotomy. This approach could prove to be effective to further increase the therapeutic
window that allows accelerating orthodontic treatment and, at the same time, could decrease
the recession risk in movements of proclination of antero-inferior incisors. Besides, the use
of a collagen scaffold alone could potentially trigger a comparable orthodontic acceleratory
outcome that could be evaluated as an alternative to decortication.
Phase:
Phase 4
Details
Lead Sponsor:
CES University
Collaborators:
Universidad del Valle, Colombia University of Michigan