A Clinical Observation on the Efficacy and Safety of Pulsed Dye Laser (PDL) in the Treatment of Nail Psoriasis
Status:
Completed
Trial end date:
2017-08-01
Target enrollment:
Participant gender:
Summary
1. Psoriasis is a common chronic, inflammatory disease characterized by skin changes and
joint involvement. About 50% of patients with psoriasis have damage to the nail,
especially in pustular psoriasis in the continuous acromegaly dermatitis. Common damage
includes pitting, uneven and tarnish of the deck, as well as the occurrence of nail
ridges, furrows, turbidity, hypertrophy, free ends and nail bed stripping, and even the
whole deck deformity or absence, etc., seriously affecting patients' social interaction
and mental health. Pathologically, telangiectasis is associated with the superficial and
middle layers of the dermis. Previous treatment of psoriasis nail is mainly topical
drugs (such as glucocorticoid, etc.), but due to its long disease period, topical drugs
are difficult to transdermal absorption, and the curative effect of skin lesions is
poor.
2. Pulsed dye laser (PDL) is effective for vasodilatory diseases, especially for the
superficial to middle layers of the dermis
3. It has been reported that PDL is effective in the treatment of psoriasis vulgis by
blocking the nutrient supply vessels of the lesions, improving the surrounding
microenvironment, reducing the number of cytotoxic T cells and helper T cells in the
dermis, and promoting the normalization of epidermal proliferation and differentiation.
4. Halometasone is a potent halogen - containing topical glucocorticoid. Have stronger
fight inflammation, fight allergy, contractive hemal, reduce hemal to connect the action
of permeability and fight hyperplasia Vaseline belongs to a kind of mineral wax, without
irritant, not easy to deteriorate, can let skin surface form a protective film when used
on the skin, let the moisture of the skin be evaporated not easily, have better protect
wet effect.
Phase:
N/A
Details
Lead Sponsor:
xjpfW
Collaborators:
Air Force General Hospital of the PLA Chinese Academy of Medical Sciences First Hospital of China Medical University