A Clinical Study to Explore Biomarkers for Drug-induced Liver Injury (DILI)
Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
This study has an open-label, one-sequence, multiple drug administration design. The purpose
of this study is as follows;
- To evaluate the change of liver function according to glutathione s-transferase (GST)
genotype after the multiple administration of amoxicillin/clavulanate.
- To evaluate the intrinsic metabolite, human leukocyte antigen (HLA) genotype, and
microRNA (miRNA) based on liver function change as the candidate biomarker for DILI.