A Clinical Study to Investigate the Effect of SAR425899 on Energy Expenditure in Obese Subjects
Status:
Completed
Trial end date:
2018-12-27
Target enrollment:
Participant gender:
Summary
Primary Objective:
To assess in overweight to obese subjects the change in sleep energy expenditure after
repeated subcutaneous (SC) doses of SAR425899.
Secondary Objectives:
- To assess the change in resting, basal and total daily energy expenditure.
- To assess the change in respiratory quotient, fat, protein and carbohydrate oxidation.
- To assess the change in body composition and core temperature.
- To assess the pharmacodynamic effects on fasting plasma glucose, biomarkers of lipid
metabolism and glycated hemoglobin (HbA1c).
- To assess the pharmacokinetic parameters for SAR425899 after repeated SC doses.
- To assess the safety and tolerability.