A Clinico-Bacteriological Study and Effect of Stress Ulcer Prophylaxis on Occurrence of Ventilator Associated Pneumonia
Status:
Completed
Trial end date:
2006-04-01
Target enrollment:
Participant gender:
Summary
Objective of this study was to determine incidence, risk factors, etiological micro-organisms
and their antimicrobial susceptibility pattern and outcome of VAP; and to study effect of
ranitidine vs. sucralfate, used for stress ulcer prophylaxis, on gastric colonization and on
occurrence of VAP.
Methods: Design: Prospective randomized study. Setting: ICUs of Medicine Department and
Anesthesiology Department, Maulana Azad Medical College and Lok Nayak Hospital, University of
Delhi, New Delhi. Patients: 50 patients of age more than 12 years, who had been on ventilator
for more than 48 hrs. Intervention: Endotracheal Aspirate and blood sample of all patients
were cultured to determine micro-organisms causing VAP and their antimicrobial susceptibility
pattern. Patients were divided into 2 groups on random basis. The first group was given
ranitidine for stress ulcer prophylaxis while the second was given sucralfate. Thereafter,
difference in gastric colonization (on basis of quantitative culture of nasogastric aspirate)
and on occurrence of VAP in both the groups was compared.
Study Hypothesis: Study was designed to create data about Ventilator associated pneumonia in
developing countries like India. This data is crucial for providing information for deciding
future guidelines for treatment of and prevention of Ventilator associated pneumonia. Further
to test the hypothesis that H2 blockers, by virtue of raising gastric Ph, increase gastric
colonization by pathogenic organism and increase incidence of Ventilator associated
pneumonia; patients were divided into two groups on random basis, as described above.