A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions

• Status: Completed
• Trial end date: 2009-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Background: Contaminated blood cultures result in unnecessary antibiotic use, increased length of stay, and additional laboratory tests, all of which increase healthcare costs. While the optimal skin antisepsis agent for reducing blood culture contamination is not known, the cost of various agents differs substantially.

Objective: To determine the relative rates of blood culture contamination for 3 skin antisepsis interventions - 10% povidone iodine aqueous solution (PI), 2% iodine tincture (IT) and 2% chlorhexidine gluconate in 70% isopropyl alcohol (CHG) - when used by dedicated phlebotomy teams to obtain peripheral blood cultures in adult non-ICU medical and surgical patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Michigan
• Collaborator: Blue Cross Blue Shield of Michigan Foundation
• Treatments: Anti-Infective Agents, Local; Cadexomer iodine; Chlorhexidine; Chlorhexidine gluconate; Ethanol; Iodine; Povidone; Povidone-Iodine

Criteria

Inclusion Criteria:

• Patient on general medical, surgical, and cardiology floors

• Receipt of a peripheral blood draw for blood culture collection

• Blood draw performed by phlebotomy team

Exclusion Criteria:

• None