A Cohort Study of Hyperthermia and Imiquimod for the Treatment of Flat Warts
Status:
Recruiting
Trial end date:
2022-06-20
Target enrollment:
Participant gender:
Summary
flat warts are a superficial viral skin disease, extremely common in childhood.Treatment of
warts is often difficult and involves different destructive procedures.Although several
pharmacological and physical topical treatments are available (keratolytic agents,
electrosurgery, cryotherapy, carbon dioxide laser), results are often unsatisfactory in terms
of efficacy (frequent recurrence) and cosmetic outcome (scars, inflammatory reactions,
transient or permanent hyper- or hypopigmentation).
Mild local Hyperthermia with a certain temperature range has been successfully used in the
treatment of some diseases. It has been utilised in the treatment of some neoplasm, fungal
and HPV infections. Investigators' study found that local hyperthermia at 44°C could cleared
HPV in more than half of the patients with plantar warts. Investigators also note the fact
that in patients with multiple lesions, the clearance of the target lesion is commonly
followed by clearance of other distant lesions, a phenomenon suggesting that local
hyperthermia could aid in establishing a specific immune response to eliminate HPV.So the
purpose of the study is to evaluation local hyperthermia in the treatment of flat warts
Appropriate control arms were designed for different conditions.