A Combined Surgical and Medical Approach in Mild Sleep Apnea

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to investigate wether the adjuvant (postoperative) administration of acetazolamide can improve the surgical results after uvulopalatopharyngoplasty in patients with mild sleep apnea.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Antwerp
• Treatments: Acetazolamide

Criteria

Inclusion Criteria:

• 5 ≤ Apnea Hypopnea Index (AHI) < 20

• Socially disturbing snoring: Visual Analogue Scale (VAS)snoring > 6/10

• Based on clinical examination and polysomnography, patient is regarded eligible for uvulopalatopharyngoplasty (UPPP)

Exclusion Criteria:

• Previous surgical treatment for sleep-disordered breathing.

• Periodic Limb Movement Disorder (PLMD) with arousals and other reasons possibly explaining the Excessive Daytime Sleepiness (EDS) based on Epworth Sleepiness Scale (ESS).

• Forced expiratory volume in 1 second (FEV1) < 80 % pred.

• Echocardiography: ejectionfraction < 35 % or dyastolic dysfunction grade 2 or more.