A Comparative Clinical and Radiographic Study of Collagen Based Pulpotomy Versus Biodentine Pulpotomy in Children With Cariously Exposed Vital Primary Molars

• Status: Not yet recruiting
• Trial end date: 2023-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Pulpotomy of vital primary molars is indicated when caries removal results in pulp exposure. Treatment approaches consist of devitalization using formocresol, preservation using ferric sulfate and regeneration of the remaining pulp tissue using mineral trioxide aggregate and recently Biodentine have been utilized.

The ideal pulpotomy medicament would be biocompatible and bactericidal, in addition, to promoting the healing of the root pulp and be compatible with the physiological process of root resorption.

Searching for more pulpotomy agents, Collagen, a protein that's present abundantly in humans, is an important component of connective tissues and performs multiple functions including wound healing.

Enamel and dentin contain Collagen as one of the components in their organic ground matrix.

Collagen has been used widely in dentistry in periodontal and implant therapy as scaffold for preventing the migration of epithelial cells and encouraging wound repopulation by cells with high regenerative potential.

The Collagen available for dental implication is already sterilized and also reinforced with antibiotic particles to efficiently aid in regeneration and repair without any contamination. The collagen particles

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University

Criteria

Inclusion Criteria:

• • Children:

1. Aged 4 to 7, in good general health and medically free.

2. Cooperative patients who will comply to follow ups.

3. Parents provided with written informed consent. • Teeth:

1. Bilaterally Carious vital primary molars with reversible pulpitis.

2. Restorable teeth with no more than 1/3 of root resorption.

Exclusion Criteria:

• • Children:

1. Children with medical, physical, or mental conditions.

2. Unable to attend follow up visits. • Teeth:

1. Primary molars with any congenital anomalies.

2. Previously accessed teeth.

3. At operative procedure, haemorrhage control is unachievable after pulpotomy.