A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non Smokers
Status:
Completed
Trial end date:
2019-07-08
Target enrollment:
Participant gender:
Summary
Smokers are at higher risk of developing Erectile dysfunction (ED) independent of age and
comorbidities. Sildenafil is a cytochrome p3A4 (CYP3A4) substrate used for enhancing the
erectile function in males. The study purpose is to determine the effect of smoking on male
sexual function based on the international index of erectile function score (IIEF) and
investigate the effect of smoking (Cigarettes or marijuana) on the pharmacokinetics and
pharmacodynamics of sildenafil.