A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection

• Status: Completed
• Trial end date: 2023-07-19
• Target enrollment: 0
• Participant gender: All

Summary

All patients who presented with epigastric pain and dyspeptic symptoms will undergo endoscopic gastric biopsies.

The patients will be subjected to: Full history taking, clinical examination, liver function tests, renal function tests, CBC, INR, abdominal ultrasonography.

About 200 patients diagnosed to have H. pylori by infection by microscopically examined, endoscopic gastric biopsies will be enrolled in our study.

All available formalin fixed and paraffin embedded tissue blocks of gastric endoscopic biopsies will be resectioned and stained with Haematoxylin and Eosin. Modified Giemsa stain, and Alcian blue/ PAS stain will be used for verification of Helicobacter pylori and demonstration of intestinal metaplasia respectively.

Biopsies will be classified using the Updated Sydney system of classification of gastritis

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helwan University
• Treatments: Clarithromycin; Metronidazole; Pantoprazole

Criteria

Inclusion Criteria:

• All patients who presented with epigastric pain and dyspeptic symptoms

Exclusion Criteria:

1. Patients recently (within 6 months) treated with anti-H. pylori therapy.

2. Allergy to any drugs used in our protocol

3. Patients on PPI, antibiotics, and steroid or non-steroidal anti-inflammatory drugs within past one month before randomization.

4. Concomitant significant comorbidities (advanced cardiac, renal, hepatic disease).

5. Presence of GI malignancy.

6. Pregnancy or lactating women.

7. Unable or refuse to give consent. -