Overview

A Comparative Study of Rimazolam and Propofol Combined With Etomidate in Gastroenteroscopy in Elderly Patients

Status:
Not yet recruiting

Trial end date:
2022-12-01

Target enrollment:
0

Participant gender:
All

Summary

Studies have shown that etomidate combined with propofol in gastroscopy has high safety and lower incidence of hypoxia and hypotension, suggesting the advantages of etomidate combined with propofol in elderly patients. Remimazolam Besylate is a 1.1 class new drug that acts on GABA receptors and is metabolized by plasma esterase with fast metabolism time, only 1/7 of midazolam, which may be more suitable for elderly patients. Therefore, this study intends to explore the safety and effectiveness of two sedation schemes in gastroenteroscopy for elderly patients.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Peking University People's Hospital

Treatments:

Etomidate
Propofol

Criteria

Inclusion Criteria:

1. Patients with asAI-III indications for painless gastroenteroscopy and receiving
diagnostic or therapeutic gastroenteroscopy;

2. Aged 60-75, body mass index (BMI) 19-28 kg/m2, Systolic blood pressure of 90-140mmHg,
diastolic blood pressure of 50-90mmHg, resting heart rate of 50-100bpm and blood pulse
oxygen saturation ≥95%

Exclusion Criteria:

1. Those who are refused to be included;

2. Those who are allergic to the drugs used in this study;

3. Epilepsy and other mental illnesses, a history of addiction such as opiates and other
analgesics and/or tranquilizers (hypnotics);

4. Severe cardiac dysfunction: NYHA cardiac functions grade 3-4, a history of recent
myocardial infarction or cerebral infarction, severe conduction block or malignant
arrhythmia;

5. Renal failure or liver cirrhosis;

6. Severe lung infection or upper respiratory tract infection;

7. Sleep apnea syndrome, difficult airway (Mallampati score of 3 or 4) or asthma status;

8. Advanced cancer accompanied by extensive intra-abdominal metastasis, acute and chronic
obstruction of the gastrointestinal tract, bleeding and severe abdominal effusion; -