A Comparison Between Propofol-Remifentanil and Midazolam-Remifentanil Sedation in the Intensive Care Unit

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare propofol-remifentanil sedation with midazolam-remifentanil sedation in regards to extubation and weaning time, length of stay in the ICU, as well as the incidence of delirium. Primary end-points were weaning time and extubation time, and secondary end-points were the incidence of delirium and length of stay in the ICU.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Midazolam; Propofol; Remifentanil

Criteria

Inclusion Criteria:

• surgical patients over 18 years old who were admitted to the ICU for postoperative ventilator care after sevoflurane-remifentanil based general anesthesia

Exclusion Criteria:

• pre-existing neurologic dysfunction (dementia)

• head trauma patients

• previous history of alcohol abuse or substance abuse

• patients who had baseline serum creatinin levels of over 2.5mg/100ml

• uncompensated liver cirrhosis

• hemorrhagic, cardiogenic, or septic shock

• pregnancy or breast feeding

• tracheostomy or extubation before ICU admission.