A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney Function
Status:
Completed
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
This is an open-label study that will measure blood levels of different parts of a drug
called GKS189075. People participating in this study will receive a single dose of 250mg
GSK189075 by mouth. About 20 people with mild to moderate decrease in renal (kidney) function
will be asked to participate in this study. They will be compared to about 20 healthy
participants who are close to the same age and body size. People participating in this study
will stay at a clinical research unit beginning 2 days before they receive their single dose
of GSK189075 and will remain there until approximately one day after receiving the study
drug. During this study urine will be collected beginning the day before receiving study drug
until the day after, just prior to leaving the clinical research unit. Blood samples will
also be collected at various times beginning immediately before until 24 hours after
receiving the study drug.