A Comparison Study Between Ketamine Versus Tramadol for Pain Management After Major Upper Abdominal Surgery
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is the comparison between ketamine and tramadol, regarding the
analgesia quality and efficiency, in patients receiving Patient Controlled Analgesia (PCA)
morphine, after major upper abdominal surgeries such as hepatectomies, gastrectomies, Whipple
procedures and peripheral pancreatectomies. The goal is to bring out an improved analgesia
scheme, which can be applied to the clinical work and refine the analgesia provided for major
procedures which require increased postoperative opioids doses. In the study, half of
patients will receive continuous intravenous infusion of tramadol and Patient Controlled
Analgesia morphine and the other half will receive continuous intravenous infusion of
ketamine and Patient Controlled Analgesia morphine postoperatively after major upper
abdominal surgery. The successful combination of different drugs targets at the improvement
of the analgesia provided, the reduction of complications and the exploitation of the
pharmacodynamic properties of each drug.