A Comparison of Analgesic Efficacy of Ultrasound-Guided Genicular Nerve Block Versus Saline Injection for Total Knee Replacement

• Status: Terminated
• Trial end date: 2021-06-21
• Target enrollment: 0
• Participant gender: All

Summary

Do ultrasound-guided genicular nerve blocks with 0.5% bupivacaine provide improved knee analgesia for patients recovering from total knee replacement surgery compared to saline injection?

Hypotheses:

The investigators hypothesize that the combination of ultrasound-guided adductor canal block (ACB) and genicular nerve block will achieve lower opioid consumption and therefore lead to decreased systemic side effects and improved overall satisfaction compared to ultrasound-guided saline injection for patients undergoing minimally invasive elective total knee arthroplasty (TKA).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Northwestern University
• Treatments: Analgesics; Bupivacaine

Criteria

Inclusion Criteria:

• Participants 40 to 85 years old who are presenting for minimally invasive total knee arthroplasty under spinal anesthesia and are candidates for peripheral nerve blocks.

• Minimally invasive is defined as custom modified instrumentation, a quadriceps sparing arthrotomy that does not extend beyond 1cm proximal to the patella and surgical techniques that focus on soft tissue protection.

Exclusion Criteria:

• Patient refusal

• American Society of Anesthesiologists physical status classification of 4 or higher

• Pre-existing neuropathy in the femoral or sciatic distribution

• Coagulopathy

• Infection at the site

• Chronic opioid use (greater than 3 months)

• Pregnancy

• Medical conditions limiting physical therapy participation

• Any other contra-indication to regional anesthesia