A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation

• Status: Completed
• Trial end date: 2019-12-27
• Target enrollment: 0
• Participant gender: All

Summary

Hypothesis: A combination of midazolam with dexmedetomidine for sedation during third molar surgery will provide 1) superior patient satisfaction, 2) superior operator satisfaction and 3) no significant hemodynamic or respiratory changes when compared to a sedation combination of midazolam, fentanyl and propofol for sedation during third molar surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Montefiore Medical Center
• Treatments: Dexmedetomidine; Fentanyl; Midazolam; Propofol

Criteria

Inclusion Criteria:

• Subject must have 3-4 partial or full bony impacted third molars requiring surgical extraction

• ASA Class I or II

• English-speaking and Spanish-speaking subjects

Exclusion Criteria:

• ASA Class III or higher

• Patients taking alpha-2 agonists or benzodiazepines

• Allergy or drug reaction to any of the drugs used in this study (benzodiazepines, opioids, propofol, alpha-2 agonists, NSAIDs, local anesthetic)

• BMI greater than 30

• History of or current substance abuse or alcoholism

• History of mood-altering medications, tranquilizers, or antidepressants.

• Pregnant females