A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients

• Status: Unknown status
• Trial end date: 2009-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to compare the effectiveness of hydrochlorothiazide or metolazone in combination with furosemide. Patients with heart failure suffer from swelling because of too much fluid in the body. Furosemide, hydrochlorothiazide, and metolazone are all water pills used to treat the swelling. For most patients, taking furosemide alone is successful. However, sometimes patients need to add another water pill. Doctors usually add either metolazone or hydrochlorothiazide. It is not clear which water pill is better when added to furosemide. The purpose of this study is to determine which water pill when added to furosemide is the best at reducing excess fluid in the body.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of New Mexico
• Treatments: Furosemide; Hydrochlorothiazide; Metolazone

Criteria

Inclusion Criteria:

• Age >18 years

• Diagnosis of chronic congestive heart failure with an ejection fraction ≤45%

• Currently on a stable regimen of furosemide consisting of a daily dose of at least 80 mg for at least two weeks.

• Patients receiving ACE-inhibitors and/or beta-blockers must be taking these medications for at least two weeks in stable doses.

Exclusion Criteria:

• Renal dysfunction (serum creatinine >2 mg/dl or creatinine clearance of <30 ml/min as calculated by the Cockroft and Gault equation)

• Hepatic dysfunction (AST and ALT >3 times the upper limit of the normal)

• Hypokalemia (<4.0 mg/dl)

• Concomitant treatment with any diuretic other than furosemide (with the exception of spironolactone).