A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters

• Status: Completed
• Trial end date: 2011-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a pilot study to compare the hemodynamic changes that occur during induction with a novel drug combination known as ketofol (propofol and ketamine admixture with that of propofol alone (prototypic anesthesia induction agent). Propofol and ketamine are widely used as induction agents and their effects on patient hemodynamics are well known. Some of these drug-induced hemodynamic changes are undesirable and lead to deleterious effects on patient hemodynamics. We seek to investigate the hemodynamic changes associated with a novel drug combination known as ketofol (ketamine/propofol admixture) during induction and compare them to propofol. If we determine that the changes produced by ketofol are favorable compared with propofol, we then will seek to test its use in the trauma setting in a subsequent randomized controlled trial.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Collaborator: Dartmouth-Hitchcock Medical Center
• Treatments: Ketamine; Propofol

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status I and II who are to undergo elective general, urologic, orthopedic, plastic, or gynecologic surgery.

Exclusion Criteria:

• patients with age less than 18 yr or over 60 yr,

• emergency surgery,

• patients undergoing neurosurgical procedures,

• any procedure with adjunctive analgesia,

• any patient on chronic opiate use,

• females who are known to be pregnant,

• patients who had ingested psychotropic or sedative medication within one month of investigation,

• patients with personality disorders,

• weight greater than 20% of ideal, and

• any known contraindications to ketamine or propofol.