A Comparison of Sertraline Versus Venlafaxine XR in the Treatment of Major Depression

• Status: Completed
• Trial end date: 2003-09-01
• Target enrollment: 0
• Participant gender: All

Summary

To assess the comparative efficacy of sertraline versus venlafaxine XR on measures of quality of life.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Pfizer; Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
• Treatments: Sertraline; Venlafaxine Hydrochloride

Criteria

Inclusion Criteria:

• Primary diagnosis of DSM-IV Major Depressive Disorder, single episode or recurrent, without psychotic features. Additional DSM-IV Axis I diagnoses will be permitted only if they are identified as secondary diagnoses.

• Hamilton-Depression rating scale (HAM-D; 17 item) total score ≥18 and HAMD item 1 (depressed mood) score ≥2.

Exclusion Criteria:

• Use of an antidepressant within 2 weeks of baseline (4 weeks for fluoxetine)

• Current or past diagnosis of bipolar disorder or any psychotic disorder.