A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Characterize the relative abuse liability of a short versus a long acting opioid in chronic pain patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, Davis
• Treatments: Acetaminophen; Amphetamine; Hydrocodone; Morphine; Phenobarbital

Criteria

Inclusion Criteria:

• Patients with chronic pain for periods greater than 6 months

• Patients taking greater than 80 mg morphine equivalents of a short acting opioid (>8 vicodin or 4 oxycodone/day)

• Referral to Pain or Substance Abuse Clinic for self-escalation of opioids

Exclusion Criteria:

• Inability to understand and comprehend spoken English

• Patients with Munchausen's syndrome

• Patient has a history of Peripheral Vascular Disease

• Patient has a history of Raynaud's Phenomenon

• Liver Disease; Child's classification greater than 1 (liver cirrhosis) will be excluded

• Renal disease (BUN >25 or Cr >1.5)

• Congestive Heart Failure; Subjects with New York Heart Association (NYHA)Heart Failure Symptom Classification System Level of Impairment II, III and IV will be excluded

• Coronary artery disease; recent MI within the past six months or recent history of angina not controlled with NTG within the past six months

• Hypertension; 1)previously normotensive subject; systolic bp >140 mm Hg and diastolic bp > 90 mm Hg 2) Hx of active treatment with antihypertensive medications; systolic bp >150 mm Hg and diastolic bp > 100 mm Hg

• Cerebrovascular disease; recent history within the past year of a transient ischemic attack or recent history within the past year of a cerebrovascular event

• Malignancy requiring active treatment

• Patient is pregnant (as ascertained by a self-report and a mandatory commercial pregnancy test before any study medication is consumed)