A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery
Status:
Completed
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
In this prospective, randomized, clinical trial, we have investigated the effects of
ketamine-based and remifentanil-based anesthetic protocol on perioperative serum cystatin-c
levels, and creatinine and/or cystatin-c based eGFR equations in terms of acute kidney injury
in CABG surgery.This study was approved by the Ethics Committee of Hospital and all patients
were informed and gave written consent. Patients scheduled for elective CABG with
cardiopulmonary bypass. Patients were randomly allocated to anesthesia with
remifentanil-propofol-midazolam (RPM) group or ketamine-propofol-midazolam (KPM) group. Blood
samples were obtained before induction of anesthesia (baseline), at the end of the operation,
and postoperative days 1, 2, and 4.
Phase:
Phase 4
Details
Lead Sponsor:
Turkiye Yuksek Ihtisas Education and Research Hospital