A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol in Intracranial Surgery

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

It was hypothesized that the use of esmolol as an alternative to remifentanil with sevoflurane inhalation anesthesia during intracranial surgery, could provide better hemodynamic conditions and cause lesser side effects in the perioperative period. It was the main objective of this study to compare the effect of esmolol and remifentanil on the incidence of tachycardia and hypertension and the intraoperative fentanyl consumption. The comparison of postoperative troponine I and creatine phosphokinase levels and EKG changes were the secondary objectives.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Diskapi Teaching and Research Hospital
• Treatments: Esmolol; Remifentanil

Criteria

Inclusion Criteria:

• Intracranial surgery

Exclusion Criteria:

• heart rate ≤ 50,

• atrioventricular block,

• sick sinus syndrome,

• heart failure,

• history of asthma,

• hypertension,

• impaired renal or hepatic function,

• patients receiving beta blockers or calcium channel blockers,

• emergency surgery.