A Crossover Study of the Acute Effects of Olanzapine in Healthy Volunteers
Status:
Completed
Trial end date:
2011-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this clinical research study is to examine the acute hormonal and metabolic
effects of the drug olanzapine, as well as appetite effects, in healthy volunteers. The
hypotheses to be tested are that: (1) Olanzapine rapidly attenuates plasma leptin and (2)
rapidly alters glucose tolerance in healthy volunteers. These questions will be answered by
having volunteers undergo two glucose tolerance tests in a crossover study design.