Overview
A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.
Status:
Recruiting
Recruiting
Trial end date:
2026-08-29
2026-08-29
Target enrollment:
0
0
Participant gender:
All
All
Summary
A phase 1, multicenter, open label, non-randomized dose escalation and dose expansion study to examine the maximum tolerated dose, (MTD), minimum effective dose (MED) and/or recommended dose for expansion (RDE) of intratumoral ONM-501 as monotherapy and in combination with a PD-1 checkpoint inhibitor in patients with advanced solid tumors and lymphomas.Phase:
Phase 1Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
OncoNano Medicine, Inc.Treatments:
Cemiplimab
Criteria
Inclusion Criteria:1. Ability to understand and willingness to sign written informed consent before
performance of any study procedures
2. Age ≥ 18 years
3. Participants with solid tumors or lymphomas, confirmed by available histopathology
records or current biopsy, that are advanced, nonresectable, or recurrent and
progressing since last antitumor therapy, and for which no alternative standard
therapy exists.
4. Participants must have a minimum of one injectable and measurable lesion.
5. Participants with prior Hepatitis B or C are eligible if they have adequate liver
function
6. Participants with human immunodeficiency virus (HIV) are eligible if on established
HAART for a minimum of 4 weeks prior to enrollment, have an HIV viral load <400
copies/mL, and have CD4+ T-cell (CD4+) counts ≥ 350 cells/uL
7. Adequate bone marrow function:
8. Adequate liver function
Exclusion Criteria: Patients will be excluded from this study if they meet any of the
following criteria (Part 1a and Part 1b).
1. Other malignancy active within the previous 2 years except for basal or squamous cell
skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix or breast
that has completed curative therapy.
2. Major surgery within 4 weeks before the first dose of study drug.
3. Brain metastases that are untreated or in the posterior fossa or involve the meninges.
Participants with stable or previously treated progressing brain metastases (except in
the posterior fossa or involving the meninges) may be permitted in a case-by-case
basis at the Sponsor's discretion.
4. Prolongation of corrected QT (QTc) interval to >470 millisecond (ms) for males and
females when electrolytes balance is normal.
5. Females who are breastfeeding or pregnant at screening or baseline
6. Females of childbearing potential that refuse to use a highly effective method of
contraception.
7. Has uncontrolled or poorly controlled hypertension as defined by a sustained BP > 9.
Has received prior investigational therapy within 5 half-lives of the agent or 4 weeks
before the first administration of study drug, whichever is shorter.
8. Has had any major cardiovascular event within 6 months prior to study drug 10. Has
known hypersensitivity to any component in the formulation of ONM-501
9. Has an active infection requiring systemic treatment
10. Is participating in another therapeutic clinical trial
Additional Exclusion Criteria for ONM-501 in Combination with cemiplimab (Part 1b)
1. Has known hypersensitivity to any component in the formulation of cemiplimab
2. Has any active or recent history of a known or suspected autoimmune disease or recent
history of a syndrome that required systemic corticosteroids (>10 mg daily prednisone
equivalent)
3. Has a condition requiring systemic treatment with corticosteroids