A Drug-Drug Interaction Study Between Sotagliflozin and Ramipril
Status:
Completed
Trial end date:
2018-03-10
Target enrollment:
Participant gender:
Summary
Primary Objective:
To evaluate the effects of multiple-dose ramipril on the steady state pharmacokinetic (PK)
parameters of sotagliflozin and its main metabolite (sotagliflozin-3-O-glucuronide) in
healthy male and female subjects.
Secondary Objectives:
- To assess the effects of multiple-dose sotagliflozin on the PK of ramipril and its
active metabolite (ramiprilat).
- To assess the safety and tolerability of multiple-dose sotagliflozin with and without
multiple-dose of ramipril.