A First-in-Human PoC Study With BEN2293 in Patients With Mild to Moderate Atopic Dermatitis

• Status: Recruiting
• Trial end date: 2022-04-06
• Target enrollment: 0
• Participant gender: All

Summary

A randomised, adaptive design, double-blind, placebo-controlled, first-in-human, two-part study to investigate the safety, tolerability, PK and preliminary efficacy of multiple topical doses of BEN2293 in patients with mild to moderate AD.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: BenevolentAI Bio

Criteria

Inclusion Criteria:

• Males and females with mild to moderate AD (based on vIGA) free from other clinically significant illness or disease that may adversely affect the safety of the patient or the integrity of the study as determined by medical history, physical examination, safety laboratory and other assessments.

• History of AD for at least 6 months diagnosed by a dermatologist or GP.

• Previous or current successful treatment with topical corticosteroids.

• A vIGA score of 2 (mild) to 3 (moderate) at both Screening and Day -1.

Exclusion Criteria:

• Atopic dermatitis of such severity that the patient could not comply with the demands of the study and/or the patient is not a suitable candidate for a placebo controlled study, as per Investigator's discretion.

• Any skin tattoo, scar, cuts, bruises, or other skin damage, including excessive UV exposure, at the possible IMP application sites.

• Patients who have AD lesions affecting >3% untreatable areas (face, scalp, genitals, palms of hands or soles of feet).

• Have concomitant skin disease or infection (e.g., acne, impetigo) or presence of skin comorbidities in the study area to be dosed that may interfere with study assessments.

• Patients who are excessively hirsute in areas of skin to be dosed with study ointment.

• Patients who are unwilling to stop hair removal by any means (including shaving, waxing or depilatory creams) to skin areas to be dosed with study ointment for 2 weeks prior to Day -1 and throughout the duration of the study.

• Clinically relevant history of abnormal physical or mental health interfering with the study as determined by medical history and physical examinations as judged by the Investigator (including [but not limited to], neurological, psychiatric, endocrine, cardiovascular, gastrointestinal, hepatic, or renal disorder).

• The patient has participated in a clinical study and has received a medication or a new chemical entity within 3 months prior to Day 1.