A Functional Magnetic Resonance Imaging (fMRI) Study in Overweight and Obese Men (0000-103)

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: Male

Summary

This study will determine whether BOLD-fMRI can be used to probe hunger and satiety states in healthy overweight or obese men and also whether fasted/fed fMRI signals can be modulated by sibutramine.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Treatments: Sibutramine

Criteria

Inclusion Criteria:

• Subject is a male between 18 and 45 years of age

• Subject has a body mass index (BMI) between 28 and 35 kg/m^2

• Subject does not weigh more than 140 kg (309 lbs) at the screening visit

• Subject is right-handed

• Subject is a non-smoker

• Subject is in generally good health

• Subject has normal or corrected to normal vision

Exclusion Criteria:

• Subject works a night shift within 3 days of each treatment visit

• Subject has permanent cosmetic or metallic objects in his body

• Subject has attention deficit hyperactivity disorder (ADHD)

• Subject has or had sleep apnea

• Subject has a history of neurological disorders

• Subject has a history of any clinically significant disease or condition

• Subject is vegan or vegetarian

• Subject has a history of eating disorders

• Subject has had previous bariatric surgery