Overview

A Laser Detection for Bladder Cancer by (Photodynamic) Spectra of Urine

Status:
Completed
Trial end date:
2016-03-01
Target enrollment:
0
Participant gender:
All
Summary
Research Problem: Bladder cancer is one of the major health concerns of the world. The present methods of diagnosis are: Ultra sound, Cystoscopy, CT scan and urine cytology. All these are stressful to the patients, particularly Cystoscopy which is commonly employed for the follow up of Bladder cancer patients. Research Significance: The present study will employ a new photodynamic diagnostic procedure to quantify a certain cancer specific biomarker called Porphyrin, which selectively binds on to the bladder cancer tissues. In this context the present technique offer viable, very easy and reliable table top instrumentation for diagnosis and continual monitoring of disease regression through urine. Research Objectives: - To quantify bladder cancer specific biomarkers such as Porphyrin using photodynamic diagnostic procedure - To find out whether this technique might be a new and easy tool for bladder cancer diagnosis only by urine. Research Methodology: The bladder cancer patients is required to swallow a chemical called ALA (5 Amino levulinic Acid hydrochloride), about 10mg/kg body weight which will play a role of biological indicator. ALA gets metabolized into certain types of porphyrins which selectively bind on to the tumor tissues (for a longer time than the normal tissues). 5ml of blood and one urine samples will be taken before using ALA. The patient must drink water then the urine will be collected after 4, 8 and 12 hours of taking ALA and the samples will be analyzed by photodynamic diagnostic procedure.
Phase:
Phase 3
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Princess Al-Johara Al-Ibrahim Cancer Research Center
Treatments:
Aminolevulinic Acid
Levulinic acid
Criteria
Inclusion Criteria:

- Patients: Urothelial (transitional cell) carcinoma. Early and advanced stages of with
transitional cell carcinoma of the bladder before transurethral resection of bladder
Tumor (TURBT) .

- Controls: Healthy volunteer's adults matched with age.

Exclusion Criteria:

- Urinary tract infection (UTI) patients

- Cardiac patients