A Mechanistic Evaluation of the Interactions Between Thermoceptive and Pruriceptive Sensory Processing
Status:
Completed
Trial end date:
2019-08-28
Target enrollment:
Participant gender:
Summary
The purpose of this human experimental study is to evaluate the pattern of itch intensity
over time in response to strong, short-term heat stimulation in two different models of
histamine and cowhage-induced itch. Moreover, the purpose is to evaluate the effect of mild
pre-heating of the skin in human experimental models of histamine, cowhage and serotonin.
Finally, we want to investigate the effect of short-term intense heat stimulation on
previously anesthetized skin.